[et_pb_section bb_built=\u00a0\u00bb1″ next_background_color=\u00a0\u00bb#000000″ inner_width=\u00a0\u00bbauto\u00a0\u00bb inner_max_width=\u00a0\u00bbnone\u00a0\u00bb][et_pb_row][et_pb_column type=\u00a0\u00bb3_4″][et_pb_text admin_label=\u00a0\u00bbIntro\u00a0\u00bb _builder_version=\u00a0\u00bb3.22.1″ module_id=\u00a0\u00bbintro\u00a0\u00bb text_text_shadow_horizontal_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ text_text_shadow_vertical_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ text_text_shadow_blur_strength=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ link_text_shadow_horizontal_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ link_text_shadow_vertical_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ link_text_shadow_blur_strength=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ ul_text_shadow_horizontal_length=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ul_text_shadow_vertical_length=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ul_text_shadow_blur_strength=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ol_text_shadow_horizontal_length=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ ol_text_shadow_vertical_length=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ ol_text_shadow_blur_strength=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ quote_text_shadow_horizontal_length=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ quote_text_shadow_vertical_length=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ quote_text_shadow_blur_strength=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ header_text_shadow_horizontal_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_text_shadow_vertical_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_text_shadow_blur_strength=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_2_text_shadow_horizontal_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_vertical_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_blur_strength=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_3_text_shadow_horizontal_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_vertical_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_blur_strength=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_4_text_shadow_horizontal_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_vertical_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_blur_strength=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_5_text_shadow_horizontal_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_vertical_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_blur_strength=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_6_text_shadow_horizontal_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_vertical_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_blur_strength=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ z_index_tablet=\u00a0\u00bb500″]<\/p>\n
La semaine derni\u00e8re, l\u2019administration am\u00e9ricaine de r\u00e9gulation des m\u00e9dicaments (Food and Drug Administration, FDA) a donn\u00e9 un avis favorable \u00e0 la qualification du syst\u00e8me algorithmique iBox, d\u00e9velopp\u00e9 par l’\u00e9quipe du Paris Transplant Group (Universit\u00e9 Paris Cit\u00e9, Inserm, AP-HP) dirig\u00e9e par le Pr Alexandre Loupy. Ceci repr\u00e9sente une premi\u00e8re permettant de virtualiser les essais cliniques et gagner ainsi de pr\u00e9cieuses ann\u00e9es dans le d\u00e9veloppement de m\u00e9dicaments. Cette \u00e9tape repr\u00e9sente une avanc\u00e9e majeure pour la m\u00e9decine pr\u00e9dictive et un espoir pour les patients transplant\u00e9s.<\/p>\n
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Une avanc\u00e9e majeure pour la m\u00e9decine pr\u00e9dictive<\/p>\n
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\u00a9 Freepik<\/p>\n<\/div>\n<\/div>\n<\/div>\n
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Une d\u00e9couverte fran\u00e7aise, port\u00e9e par un large consortium international<\/strong><\/p>\n Fruit de 15 ann\u00e9es de recherche, l\u2019iBox a vu le jour en 2019 sous la direction du Pr Alexandre Loupy et de son \u00e9quipe. Cet algorithme, bas\u00e9 sur l\u2019analyse de plus de 85 param\u00e8tres pr\u00e9- et post-transplantation, permet de pr\u00e9dire, d\u00e8s les premiers mois apr\u00e8s une greffe r\u00e9nale, le devenir du greffon sur une p\u00e9riode allant jusqu\u2019\u00e0 10 ans. Ces travaux, publi\u00e9s dans la revue scientifique BMJ<\/em> en 2019, puis dans le Lancet Digital health, Nature Medicine, Kidney international, Transplant international et American Journal of Transplantation en 2024 re\u00e7u de nombreuses distinctions, notamment celles de l\u2019Acad\u00e9mie nationale de m\u00e9decine, mais aussi le prix de la soci\u00e9t\u00e9 Am\u00e9ricaine de Transplantation d\u00e9cern\u00e9 pour la premi\u00e8re fois \u00e0 un Fran\u00e7ais.<\/p>\n Valid\u00e9 dans 12 centres europ\u00e9ens et am\u00e9ricains ainsi que dans 3 essais cliniques randomis\u00e9s, l\u2019iBox a ensuite b\u00e9n\u00e9fici\u00e9 du soutien de la soci\u00e9t\u00e9 Am\u00e9ricane de Transplantation (AST) du Transplant Therapeutics Consortium (TTC), un partenariat international r\u00e9unissant experts scientifiques, industriels et autorit\u00e9s r\u00e9glementaires, dont la FDA. Ce soutien, renforc\u00e9 par des contributions de grandes entreprises pharmaceutiques comme Novartis, Sanofi ou Bristol Myers Squibb, a permis \u00e0 l\u2019algorithme de franchir des \u00e9tapes cruciales vers sa reconnaissance mondiale.<\/p>\n Apr\u00e8s avoir \u00e9t\u00e9 qualifi\u00e9 par l\u2019Agence europ\u00e9enne des m\u00e9dicaments (EMA) en d\u00e9cembre 2022, l\u2019iBox vient d\u2019obtenir une validation par la FDA aux \u00c9tats-Unis, consolidant sa place comme outil de r\u00e9f\u00e9rence en m\u00e9decine pr\u00e9dictive pour la transplantation r\u00e9nale. Fruit d\u2019un travail gigantesque en collaboration \u00e9troite avec les soci\u00e9t\u00e9s savantes Am\u00e9ricaines @ast @asts, port\u00e9 par les associations de patients US et le Transplant therapeutic consortium @bill Flizimons<\/p>\n Un tournant dans la recherche clinique et le suivi m\u00e9dical<\/strong><\/p>\n L\u2019iBox ne se contente pas de pr\u00e9dire l\u2019\u00e9tat des greffons : il offre aux cliniciens une vision d\u00e9taill\u00e9e des trajectoires possibles de d\u00e9clin fonctionnel, permettant un ajustement pr\u00e9cis des traitements. Par exemple, il peut d\u00e9tecter rapidement les effets d\u2019un changement th\u00e9rapeutique sur la survie \u00e0 long terme d\u2019un greffon.<\/p>\n Les b\u00e9n\u00e9fices pour les syst\u00e8mes de sant\u00e9 sont \u00e9galement majeurs. En optimisant l\u2019utilisation des ressources m\u00e9dicales et en \u00e9vitant les traitements inefficaces, l\u2019iBox contribue \u00e0 r\u00e9duire les co\u00fbts tout en am\u00e9liorant la qualit\u00e9 des soins.<\/p>\n Le Pr Jon Kobashigawa, pr\u00e9sident de l\u2019@American Society of Transplantation, souligne :<\/p>\n \u00ab L’alignement de l\u2019iBox sur la qualification FDA nous rapproche d’outils cliniques de pointe capables de prolonger la vie des patients transplant\u00e9s. Cette innovation marque un tournant dans la modernisation des essais cliniques et du suivi m\u00e9dical. \u00bb<\/em><\/p>\n Vers une r\u00e9volution au-del\u00e0 de la transplantation r\u00e9nale<\/strong><\/p>\n L\u2019impact de l\u2019iBox d\u00e9passe le cadre des greffes r\u00e9nales. Son mod\u00e8le algorithmique pourrait \u00eatre adapt\u00e9 \u00e0 d\u2019autres sp\u00e9cialit\u00e9s m\u00e9dicales, introduisant une nouvelle \u00e8re pour la m\u00e9decine pr\u00e9dictive et les essais cliniques. Une innovation fran\u00e7aise, d\u00e9sormais reconnue mondialement, qui pourrait transformer durablement le paysage m\u00e9dical.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_4″][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=\u00a0\u00bb1″ specialty=\u00a0\u00bboff\u00a0\u00bb _builder_version=\u00a0\u00bb3.21″ custom_padding=\u00a0\u00bb0px||0px|\u00a0\u00bb prev_background_color=\u00a0\u00bb#000000″ inner_width=\u00a0\u00bbauto\u00a0\u00bb inner_max_width=\u00a0\u00bbnone\u00a0\u00bb][et_pb_row _builder_version=\u00a0\u00bb3.19.11″ width=\u00a0\u00bb80%\u00a0\u00bb max_width=\u00a0\u00bb1080px\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″][et_pb_text admin_label=\u00a0\u00bb\u00c0 lire aussi\u00a0\u00bb _builder_version=\u00a0\u00bb3.21″]<\/p>\n [\/et_pb_text][et_pb_blog _builder_version=\u00a0\u00bb3.21″ posts_number=\u00a0\u00bb4″ include_categories=\u00a0\u00bb13″ show_author=\u00a0\u00bboff\u00a0\u00bb show_date=\u00a0\u00bboff\u00a0\u00bb show_pagination=\u00a0\u00bboff\u00a0\u00bb border_width_bottom_fullwidth=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom_fullwidth=\u00a0\u00bbrgba(51,51,51,0.18)\u00a0\u00bb custom_padding=\u00a0\u00bb||50px|\u00a0\u00bb module_id=\u00a0\u00bbpage_type_blog\u00a0\u00bb header_level=\u00a0\u00bbh4″ \/][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"\u00c0<\/span> lire aussi<\/h2>\n