{"id":12375,"date":"2024-12-17T17:56:19","date_gmt":"2024-12-17T16:56:19","guid":{"rendered":"https:\/\/u-paris.fr\/sante\/?p=12375"},"modified":"2025-01-02T11:41:50","modified_gmt":"2025-01-02T10:41:50","slug":"une-avancee-prometteuse-pour-les-patients-atteints-de-lupus","status":"publish","type":"post","link":"https:\/\/u-paris.fr\/sante\/une-avancee-prometteuse-pour-les-patients-atteints-de-lupus\/","title":{"rendered":"Une avanc\u00e9e prometteuse pour les patients atteints de Lupus"},"content":{"rendered":"

[et_pb_section bb_built=\u00a0\u00bb1″ next_background_color=\u00a0\u00bb#000000″ inner_width=\u00a0\u00bbauto\u00a0\u00bb inner_max_width=\u00a0\u00bbnone\u00a0\u00bb][et_pb_row][et_pb_column type=\u00a0\u00bb3_4″][et_pb_text admin_label=\u00a0\u00bbIntro\u00a0\u00bb _builder_version=\u00a0\u00bb3.22.1″ module_id=\u00a0\u00bbintro\u00a0\u00bb text_text_shadow_horizontal_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ text_text_shadow_vertical_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ text_text_shadow_blur_strength=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ link_text_shadow_horizontal_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ link_text_shadow_vertical_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ link_text_shadow_blur_strength=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ ul_text_shadow_horizontal_length=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ul_text_shadow_vertical_length=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ul_text_shadow_blur_strength=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ol_text_shadow_horizontal_length=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ ol_text_shadow_vertical_length=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ ol_text_shadow_blur_strength=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ quote_text_shadow_horizontal_length=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ quote_text_shadow_vertical_length=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ quote_text_shadow_blur_strength=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ header_text_shadow_horizontal_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_text_shadow_vertical_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_text_shadow_blur_strength=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_2_text_shadow_horizontal_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_vertical_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_blur_strength=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_3_text_shadow_horizontal_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_vertical_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_blur_strength=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_4_text_shadow_horizontal_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_vertical_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_blur_strength=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_5_text_shadow_horizontal_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_vertical_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_blur_strength=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_6_text_shadow_horizontal_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_vertical_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_blur_strength=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ z_index_tablet=\u00a0\u00bb500″]<\/p>\n

L’\u00e9quipe du Pr Dominique Farge (AP-HP, Universit\u00e9 Paris-Cit\u00e9), en collaboration avec celles du Pr Mark Lowdell (UCL, Londres) et du Pr Karin Tarte (CHU de Rennes) ont d\u00e9montr\u00e9 pour la premi\u00e8re fois qu\u2019il est possible et s\u00fbr d\u2019administrer des cellules stromales m\u00e9senchymateuses issues du cordon ombilical \u00e0 des patients atteints de Lupus \u00c9ryth\u00e9mateux Syst\u00e9mique s\u00e9v\u00e8re, une maladie auto-immune difficile \u00e0 traiter. Les r\u00e9sultats ont \u00e9t\u00e9 publi\u00e9s le 17 d\u00e9cembre 2024 dans The Lancet Rheumatology<\/em>.<\/p>\n

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header_5_text_shadow_blur_strength=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_6_text_shadow_horizontal_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_vertical_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_blur_strength=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ z_index_tablet=\u00a0\u00bb500″]<\/p>\n

Des r\u00e9sultats cl\u00e9s<\/h2>\n

Cette \u00e9tude de phase I a \u00e9t\u00e9 coordonn\u00e9e par le Pr Dominique Farge du Centre de R\u00e9f\u00e9rence (CRMR MATHEC), maladies auto-immunes et th\u00e9rapie cellulaire de l\u2019h\u00f4pital Saint-Louis AP-HP et Universit\u00e9 Paris-Cite et de l\u2019URP 3518 Recherche Clinique appliqu\u00e9e \u00e0 l\u2019h\u00e9matologie, Universit\u00e9 Paris Cit\u00e9. Elle a port\u00e9 sur 8 patients souffrant de formes graves de lupus, r\u00e9sistantes aux traitements immunosuppresseurs habituels. Les cellules utilis\u00e9es ont \u00e9t\u00e9 pr\u00e9par\u00e9es \u00e0 partir de tissus du cordon ombilical \u00e0 Londres, puis administr\u00e9es par une simple perfusion intraveineuse. Aucun effet secondaire grave n\u2019ayant \u00e9t\u00e9 observ\u00e9 dans les 10 jours suivant l\u2019injection, la s\u00e9curit\u00e9 est prouv\u00e9e. Certains patients ont connu une stabilisation rapide de la maladie, avec des r\u00e9missions pouvant durer jusqu\u2019\u00e0 un an.<\/p>\n

Ces r\u00e9sultats sont enthousiasmants car ils montrent que cette th\u00e9rapie cellulaire innovante pourrait offrir une nouvelle option th\u00e9rapeutique aux patients dont les traitements traditionnels \u00e9chouent. Ils peuvent \u00eatre consult\u00e9s ici (en anglais),<\/a> avec l\u2019ensemble de l\u2019article du Lancet Rheumatology. <\/em><\/p>\n

Pourquoi c\u2019est important ?<\/h2>\n

Le lupus est une maladie auto-immune chronique et s\u00e9v\u00e8re qui touche plusieurs organes (peau, articulations, reins, etc.) avec des pouss\u00e9es inflammatoires difficiles \u00e0 ma\u00eetriser. Si la plupart des patients rentrent en r\u00e9mission gr\u00e2ce aux traitements conventionnels, environ 15 \u00e0 20 % d\u2019entre eux ne r\u00e9pondent pas aux traitements classiques et font face \u00e0 un risque accru de complications graves.<\/p>\n

Comme l\u2019indique le Pr Dominique Fargue, \u00ab\u00a0Les r\u00e9sultats cliniques observ\u00e9s ont permis pour certains patients des mises en remissions durables et un net b\u00e9n\u00e9fique clinique \u00e0 court terme. Ces donn\u00e9es sugg\u00e8rent que cette innovation th\u00e9rapeutique peut avoir un effet pr\u00e9coce sur la stabilisation de la maladie, susceptible de se maintenir au moins un an apr\u00e8s l\u2019injection.\u00a0\u00bb<\/em><\/p>\n

Perspectives futures<\/h2>\n

Les chercheurs souhaitent maintenant mener des \u00e9tudes plus vastes pour :<\/p>\n

    \n
  1. \u00c9valuer l\u2019efficacit\u00e9 des perfusions r\u00e9p\u00e9t\u00e9es de cellules stromales.<\/li>\n
  2. Mieux comprendre comment ces cellules agissent sur les d\u00e9fenses immunitaires pour calmer l\u2019hyperactivit\u00e9 des lymphocytes B responsables de la maladie.<\/li>\n<\/ol>\n

    Cette recherche a \u00e9t\u00e9 soutenue par l\u2019Assistance Publique \u2013 H\u00f4pitaux de Paris, a \u00e9t\u00e9 financ\u00e9e par le prix \u201cTh\u00e9rapie g\u00e9nique et cellulaire\u201d attribu\u00e9 au Pr Farge en 2014 par la Fondation du Rein et l\u2019Alliance Maladies Rares AFM- T\u00e9l\u00e9thon, la Direction de la Recherche Clinique et de l\u2019Innovation AP-HP, et l\u2019Agence Nationale de la Recherche (Programme Infrastructures Ecell).\u00a0 Elle ouvre la voie \u00e0 des traitements innovants pour am\u00e9liorer la qualit\u00e9 de vie des patients atteints de lupus et d\u2019autres maladies auto-immunes s\u00e9v\u00e8res.<\/p>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_4″][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=\u00a0\u00bb1″ specialty=\u00a0\u00bboff\u00a0\u00bb _builder_version=\u00a0\u00bb3.21″ custom_padding=\u00a0\u00bb0px||0px|\u00a0\u00bb prev_background_color=\u00a0\u00bb#000000″ inner_width=\u00a0\u00bbauto\u00a0\u00bb inner_max_width=\u00a0\u00bbnone\u00a0\u00bb][et_pb_row _builder_version=\u00a0\u00bb3.19.11″ width=\u00a0\u00bb80%\u00a0\u00bb max_width=\u00a0\u00bb1080px\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″][et_pb_text admin_label=\u00a0\u00bb\u00c0 lire aussi\u00a0\u00bb _builder_version=\u00a0\u00bb3.21″]<\/p>\n

    \u00c0<\/span> lire aussi<\/h2>\n

    [\/et_pb_text][et_pb_blog _builder_version=\u00a0\u00bb3.21″ posts_number=\u00a0\u00bb4″ include_categories=\u00a0\u00bb13″ show_author=\u00a0\u00bboff\u00a0\u00bb show_date=\u00a0\u00bboff\u00a0\u00bb show_pagination=\u00a0\u00bboff\u00a0\u00bb border_width_bottom_fullwidth=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom_fullwidth=\u00a0\u00bbrgba(51,51,51,0.18)\u00a0\u00bb custom_padding=\u00a0\u00bb||50px|\u00a0\u00bb module_id=\u00a0\u00bbpage_type_blog\u00a0\u00bb header_level=\u00a0\u00bbh4″ \/][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

    \n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div> L’\u00e9quipe du Pr Dominique Farge (AP-HP, Universit\u00e9 Paris-Cit\u00e9), en collaboration avec celles du Pr Mark Lowdell (UCL, Londres) et du Pr Karin Tarte (CHU de Rennes) ont d\u00e9montr\u00e9 pour la premi\u00e8re fois qu\u2019il est possible et s\u00fbr d\u2019administrer des cellules stromales m\u00e9senchymateuses issues du cordon ombilical \u00e0 des patients atteints de Lupus \u00c9ryth\u00e9mateux Syst\u00e9mique… Lire la suite Une avanc\u00e9e prometteuse pour les patients atteints de Lupus<\/span><\/a><\/p>\n","protected":false},"author":185,"featured_media":12377,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[17],"tags":[],"coauthors":[52],"class_list":["post-12375","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recherche"],"_links":{"self":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/12375","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/users\/185"}],"replies":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/comments?post=12375"}],"version-history":[{"count":6,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/12375\/revisions"}],"predecessor-version":[{"id":12406,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/12375\/revisions\/12406"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/media\/12377"}],"wp:attachment":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/media?parent=12375"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/categories?post=12375"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/tags?post=12375"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/coauthors?post=12375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}