{"id":12643,"date":"2025-03-03T10:38:44","date_gmt":"2025-03-03T09:38:44","guid":{"rendered":"https:\/\/u-paris.fr\/sante\/?p=12643"},"modified":"2025-03-03T10:38:44","modified_gmt":"2025-03-03T09:38:44","slug":"nouvelles-avancees-sur-le-role-des-anticorps-anti-pf4-h-dans-les-pathologies-thrombotiques","status":"publish","type":"post","link":"https:\/\/u-paris.fr\/sante\/nouvelles-avancees-sur-le-role-des-anticorps-anti-pf4-h-dans-les-pathologies-thrombotiques\/","title":{"rendered":"Nouvelles avanc\u00e9es sur le r\u00f4le des anticorps anti-PF4\/H dans les pathologies thrombotiques"},"content":{"rendered":"

[et_pb_section bb_built=\u00a0\u00bb1″ next_background_color=\u00a0\u00bb#000000″ inner_width=\u00a0\u00bbauto\u00a0\u00bb inner_max_width=\u00a0\u00bbnone\u00a0\u00bb][et_pb_row][et_pb_column type=\u00a0\u00bb3_4″][et_pb_text admin_label=\u00a0\u00bbIntro\u00a0\u00bb _builder_version=\u00a0\u00bb3.22.1″ module_id=\u00a0\u00bbintro\u00a0\u00bb text_text_shadow_horizontal_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ text_text_shadow_vertical_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ text_text_shadow_blur_strength=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ link_text_shadow_horizontal_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ link_text_shadow_vertical_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ link_text_shadow_blur_strength=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ ul_text_shadow_horizontal_length=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ul_text_shadow_vertical_length=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ul_text_shadow_blur_strength=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ol_text_shadow_horizontal_length=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ ol_text_shadow_vertical_length=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ ol_text_shadow_blur_strength=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ quote_text_shadow_horizontal_length=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ quote_text_shadow_vertical_length=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ quote_text_shadow_blur_strength=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ header_text_shadow_horizontal_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_text_shadow_vertical_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_text_shadow_blur_strength=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_2_text_shadow_horizontal_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_vertical_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_blur_strength=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_3_text_shadow_horizontal_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_vertical_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_blur_strength=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_4_text_shadow_horizontal_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_vertical_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_blur_strength=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_5_text_shadow_horizontal_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_vertical_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_blur_strength=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_6_text_shadow_horizontal_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_vertical_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_blur_strength=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ z_index_tablet=\u00a0\u00bb500″]<\/p>\n

La thrombop\u00e9nie induite par l’h\u00e9parine (TIH) est une complication de l\u2019h\u00e9mostase, les ph\u00e9nom\u00e8nes physiologiques qui concourent \u00e0 la pr\u00e9vention et \u00e0 l’arr\u00eat des saignements,<\/span><\/span> entra\u00eenant des thromboses apr\u00e8s une exposition \u00e0 l’h\u00e9parine. L’\u00e9quipe \u00ab\u00a0Endoth\u00e9liopathie et troubles de l’h\u00e9mostase\u00a0\u00bb du Paris Centre de Recherche Cardiovasculaire (UMRS 970 PARCC), dirig\u00e9e par le Pr David Smadja, a publi\u00e9 en f\u00e9vrier 2025 deux articles importants \u00e0 propos d’une possibilit\u00e9 de traitement sans anticoagulant.<\/p>\n

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La thrombose veineuse correspond \u00e0 un caillot de sang qui se forme dans une veine.<\/div>\n<\/div>\n<\/div>\n

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\u00a9 Freepix<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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La thrombop\u00e9nie induite par l’h\u00e9parine (TIH) et la VITT<\/h2>\n

La thrombop\u00e9nie induite par l’h\u00e9parine (TIH) est une complication sanguine qui provoque des caillots apr\u00e8s l’administration d’h\u00e9parine, un anticoagulant. Elle est caract\u00e9ris\u00e9e par une diminution des plaquettes et la pr\u00e9sence d\u2019anticorps sp\u00e9cifiques. En 2021, une autre maladie rare, la \u00ab\u00a0Vaccine-Induced Immune Thrombosis and Thrombocytopenia\u00a0\u00bb (VITT), a \u00e9t\u00e9 d\u00e9couverte apr\u00e8s la vaccination contre la COVID-19 avec des vaccins \u00e0 ad\u00e9novirus. Contrairement \u00e0 la TIH, la VITT est caus\u00e9e par des anticorps anti-PF4 diff\u00e9rents, qui activent les plaquettes sans besoin d\u2019h\u00e9parine.<\/p>\n

Deux nouvelles \u00e9tudes sur les anticorps anti-PF4\/H<\/h2>\n

En f\u00e9vrier 2025, l’\u00e9quipe \u00ab\u00a0Endoth\u00e9liopathie et troubles de l’h\u00e9mostase\u00a0\u00bb du Paris Centre de Recherche Cardiovasculaire (UMRS 970 PARCC), dirig\u00e9e par le Pr David Smadja, a publi\u00e9 deux \u00e9tudes majeures :<\/p>\n

Dans sa premi\u00e8re \u00e9tude, <\/em>publi\u00e9e dans Research and Practice in Thrombosis and Haemostasis<\/em> (RPTH), <\/strong>l’\u00e9quipe du Pr David Smadja a analys\u00e9 le r\u00f4le des anticorps anti-PF4\/H durant la COVID-19 et apr\u00e8s la vaccination. Gr\u00e2ce \u00e0 plusieurs collaborations (SARCODO<\/em>, COVADIS<\/em>, COVID-HOP<\/em>, et l\u2019Universit\u00e9 de Vienne), elle a confirm\u00e9 que ni la COVID-19 ni la vaccination ne provoquent une augmentation significative de ces anticorps. De plus, elle a mis en \u00e9vidence des diff\u00e9rences d\u2019activation des plaquettes entre la TIH et la VITT.<\/p>\n

Dans sa seconde \u00e9tude, <\/em>publi\u00e9e au New England Journal of Medicine<\/em>, l’\u00e9quipe \u00ab\u00a0Endoth\u00e9liopathie et troubles de l’h\u00e9mostase\u00a0\u00bb a\u00a0 \u00e9tudi\u00e9 cinq patients dans plusieurs pays (France, Espagne, Allemagne, Nouvelle-Z\u00e9lande, Canada) atteints d\u2019une maladie sanguine appel\u00e9e gammapathie monoclonale de signification ind\u00e9termin\u00e9e<\/em> (MGUS). Ces patients pr\u00e9sentaient des caillots sanguins inhabituels et une diminution des plaquettes. L\u2019analyse a r\u00e9v\u00e9l\u00e9 la pr\u00e9sence d\u2019anticorps anti-PF4 actifs, permettant d\u2019identifier une nouvelle maladie : les gammapathies monoclonales thrombotiques de type VITT-like<\/em>.<\/p>\n

Implications et perspectives<\/h2>\n

Ces patients, plus jeunes que ceux atteints de MGUS classique, d\u00e9veloppent des anticorps prothrombotiques similaires \u00e0 ceux de la VITT apr\u00e8s vaccination. Il est donc crucial de rechercher ces anticorps en cas de caillots sanguins associ\u00e9s \u00e0 une baisse des plaquettes pour mieux diagnostiquer et traiter ces troubles.<\/p>\n

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\u00c0<\/span> lire aussi<\/h2>\n

[\/et_pb_text][et_pb_blog _builder_version=\u00a0\u00bb3.21″ posts_number=\u00a0\u00bb4″ include_categories=\u00a0\u00bb13″ show_author=\u00a0\u00bboff\u00a0\u00bb show_date=\u00a0\u00bboff\u00a0\u00bb show_pagination=\u00a0\u00bboff\u00a0\u00bb border_width_bottom_fullwidth=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom_fullwidth=\u00a0\u00bbrgba(51,51,51,0.18)\u00a0\u00bb custom_padding=\u00a0\u00bb||50px|\u00a0\u00bb module_id=\u00a0\u00bbpage_type_blog\u00a0\u00bb header_level=\u00a0\u00bbh4″ \/][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div> La thrombop\u00e9nie induite par l’h\u00e9parine (TIH) est une complication de l\u2019h\u00e9mostase, les ph\u00e9nom\u00e8nes physiologiques qui concourent \u00e0 la pr\u00e9vention et \u00e0 l’arr\u00eat des saignements, entra\u00eenant des thromboses apr\u00e8s une exposition \u00e0 l’h\u00e9parine. L’\u00e9quipe \u00ab\u00a0Endoth\u00e9liopathie et troubles de l’h\u00e9mostase\u00a0\u00bb du Paris Centre de Recherche Cardiovasculaire (UMRS 970 PARCC), dirig\u00e9e par le Pr David Smadja, a… Lire la suite Nouvelles avanc\u00e9es sur le r\u00f4le des anticorps anti-PF4\/H dans les pathologies thrombotiques<\/span><\/a><\/p>\n","protected":false},"author":185,"featured_media":12645,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[1,17],"tags":[],"coauthors":[52],"class_list":["post-12643","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculte-de-sante","category-recherche"],"_links":{"self":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/12643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/users\/185"}],"replies":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/comments?post=12643"}],"version-history":[{"count":1,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/12643\/revisions"}],"predecessor-version":[{"id":12646,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/12643\/revisions\/12646"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/media\/12645"}],"wp:attachment":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/media?parent=12643"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/categories?post=12643"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/tags?post=12643"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/coauthors?post=12643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}