{"id":12859,"date":"2025-03-21T17:05:51","date_gmt":"2025-03-21T16:05:51","guid":{"rendered":"https:\/\/u-paris.fr\/sante\/?p=12859"},"modified":"2025-03-27T12:30:11","modified_gmt":"2025-03-27T11:30:11","slug":"la-thrombine-un-contributeur-potentiel-a-la-preeclampsie","status":"publish","type":"post","link":"https:\/\/u-paris.fr\/sante\/la-thrombine-un-contributeur-potentiel-a-la-preeclampsie\/","title":{"rendered":"La thrombine, un contributeur potentiel \u00e0 la pr\u00e9\u00e9clampsie"},"content":{"rendered":"

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En France, 1 \u00e0 2% des grossesses s\u2019accompagnent de pr\u00e9\u00e9clampsie, une maladie augmentant la pression art\u00e9rielle et causant des l\u00e9sions organiques, notamment au niveau des reins. Cette maladie est responsable d\u2019un tiers des naissances de grands pr\u00e9matur\u00e9s en France. Divina El Hamaoui, dans sa th\u00e8se dirig\u00e9e par la professeure Elisa Rossi de l\u2019Universit\u00e9 Paris Cit\u00e9 (IThEM: Innovative Therapies in Hemostasis), s\u2019int\u00e9resse au lien entre la thrombine et les mol\u00e9cules d\u2019endogline solubles, ce qui a fait l\u2019objet d\u2019une publication scientifique dans la revue Communications Biology<\/em> le 26 f\u00e9vrier 2025.<\/p>\n<\/div>\n<\/div>\n<\/div>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_4″][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb3.19.11″ module_id=\u00a0\u00bbimage-page-type\u00a0\u00bb width=\u00a0\u00bb80%\u00a0\u00bb max_width=\u00a0\u00bb1080px\u00a0\u00bb][et_pb_column type=\u00a0\u00bb3_4″][et_pb_image admin_label=\u00a0\u00bbImage 1920 x 1080″ _builder_version=\u00a0\u00bb3.22.1″ src=\u00a0\u00bbhttps:\/\/u-paris.fr\/sante\/wp-content\/uploads\/sites\/19\/2025\/03\/femmeenceinte.jpg\u00a0\u00bb module_id=\u00a0\u00bbimage-page\u00a0\u00bb z_index_tablet=\u00a0\u00bb500″ \/][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_4″][et_pb_text admin_label=\u00a0\u00bbTexte image\u00a0\u00bb _builder_version=\u00a0\u00bb3.22.1″ module_id=\u00a0\u00bbtexte-image\u00a0\u00bb custom_margin=\u00a0\u00bb|-15px||\u00a0\u00bb text_text_shadow_horizontal_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ text_text_shadow_vertical_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ text_text_shadow_blur_strength=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ link_text_shadow_horizontal_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ link_text_shadow_vertical_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ link_text_shadow_blur_strength=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ ul_text_shadow_horizontal_length=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ul_text_shadow_vertical_length=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ul_text_shadow_blur_strength=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ol_text_shadow_horizontal_length=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ ol_text_shadow_vertical_length=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ ol_text_shadow_blur_strength=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ quote_text_shadow_horizontal_length=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ quote_text_shadow_vertical_length=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ quote_text_shadow_blur_strength=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ header_text_shadow_horizontal_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_text_shadow_vertical_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_text_shadow_blur_strength=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_2_text_shadow_horizontal_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_vertical_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_blur_strength=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_3_text_shadow_horizontal_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_vertical_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_blur_strength=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_4_text_shadow_horizontal_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_vertical_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_blur_strength=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_5_text_shadow_horizontal_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_vertical_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_blur_strength=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_6_text_shadow_horizontal_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_vertical_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_blur_strength=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ z_index_tablet=\u00a0\u00bb500″]<\/p>\n

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La pr\u00e9\u00e9clampsie r\u00e9sulte d\u2019un dysfonctionnement du placenta.<\/div>\n<\/div>\n<\/div>\n

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Pr\u00e9\u00e9clampsie et endogline<\/h2>\n

Chez les femmes atteintes de pr\u00e9\u00e9clampsie, on retrouve en grande quantit\u00e9 une mol\u00e9cule, appel\u00e9e endogline soluble, dans le sang et les urines. C\u2019est ce qu\u2019on appelle un biomarqueur de la maladie. Cette mol\u00e9cule, normalement situ\u00e9e sur la membrane des cellules, est lib\u00e9r\u00e9e gr\u00e2ce \u00e0 l\u2019action d\u2019enzymes. Jusqu\u2019\u00e0 pr\u00e9sent, on ne savait pas que la thrombine faisait partie des enzymes pouvant la lib\u00e9rer ou, plus pr\u00e9cis\u00e9ment, la d\u00e9couper.\u00a0C\u2019est ce que d\u00e9montre l\u2019\u00e9tude.<\/p>\n

De l\u2019endogline \u00e0 l\u2019endogline soluble<\/h2>\n

Pour \u00e9tudier l\u2019action de la thrombine sur l\u2019endogline, des tests ont \u00e9t\u00e9 r\u00e9alis\u00e9s lors d\u2019\u00e9tudes cliniques (analyse du sang de femmes atteintes de pr\u00e9\u00e9clampsie) mais aussi in vitro en ajoutant de la thrombine \u00e0 de l\u2019endogline purifi\u00e9e. Dans les deux cas, les r\u00e9sultats sont probants: il y a (beaucoup) plus d\u2019endogline soluble en pr\u00e9sence de thrombine. On observe m\u00eame de l\u2019endogline soluble de diff\u00e9rentes tailles. Cela montre que la thrombine peut bien couper l\u2019endogline \u00e0 plusieurs endroits, conduisant ainsi \u00e0 l\u2019englobine soluble pr\u00e9sente dans le sang. Elle pourrait donc contribuer au d\u00e9veloppement de la pr\u00e9\u00e9clampsie et entra\u00eener des l\u00e9sions des vaisseaux sanguins.<\/p>\n

Perspectives de la d\u00e9couverte<\/h2>\n

Cette d\u00e9couverte peut avoir plusieurs applications. Elle pourrait permettre d\u2019avoir d\u2019autres tests de d\u00e9tection de la pr\u00e9\u00e9clampsie se basant sur la d\u00e9tection de thrombine, par exemple. En am\u00e9liorant notre connaissance de la pr\u00e9\u00e9clampsie, de telles d\u00e9couvertes peuvent, \u00e0 terme, mener \u00e0 de nouveaux traitements!<\/p>\n

\u00a0<\/p>\n

Source\u00a0<\/strong>: El Hamaoui, D., Marchelli, A., Gandrille, S. et al.<\/em> Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia. Commun Biol<\/em> 8<\/strong>, 316 (2025). https:\/\/doi.org\/10.1038\/s42003-025-07751-3<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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\u00c0<\/span> lire aussi<\/h2>\n

[\/et_pb_text][et_pb_blog _builder_version=\u00a0\u00bb3.21″ posts_number=\u00a0\u00bb4″ include_categories=\u00a0\u00bb13″ show_author=\u00a0\u00bboff\u00a0\u00bb show_date=\u00a0\u00bboff\u00a0\u00bb show_pagination=\u00a0\u00bboff\u00a0\u00bb border_width_bottom_fullwidth=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom_fullwidth=\u00a0\u00bbrgba(51,51,51,0.18)\u00a0\u00bb custom_padding=\u00a0\u00bb||50px|\u00a0\u00bb module_id=\u00a0\u00bbpage_type_blog\u00a0\u00bb header_level=\u00a0\u00bbh4″ \/][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div> En France, 1 \u00e0 2% des grossesses s\u2019accompagnent de pr\u00e9\u00e9clampsie, une maladie augmentant la pression art\u00e9rielle et causant des l\u00e9sions organiques, notamment au niveau des reins. Cette maladie est responsable d\u2019un tiers des naissances de grands pr\u00e9matur\u00e9s en France. Divina El Hamaoui, dans sa th\u00e8se dirig\u00e9e par la professeure Elisa Rossi de l\u2019Universit\u00e9 Paris… Lire la suite La thrombine, un contributeur potentiel \u00e0 la pr\u00e9\u00e9clampsie<\/span><\/a><\/p>\n","protected":false},"author":605,"featured_media":12897,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[1,17],"tags":[],"coauthors":[56],"class_list":["post-12859","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculte-de-sante","category-recherche"],"_links":{"self":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/12859","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/users\/605"}],"replies":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/comments?post=12859"}],"version-history":[{"count":9,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/12859\/revisions"}],"predecessor-version":[{"id":12871,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/12859\/revisions\/12871"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/media\/12897"}],"wp:attachment":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/media?parent=12859"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/categories?post=12859"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/tags?post=12859"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/coauthors?post=12859"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}