{"id":12917,"date":"2025-03-31T11:45:54","date_gmt":"2025-03-31T09:45:54","guid":{"rendered":"https:\/\/u-paris.fr\/sante\/?p=12917"},"modified":"2025-04-01T15:33:23","modified_gmt":"2025-04-01T13:33:23","slug":"12917-2","status":"publish","type":"post","link":"https:\/\/u-paris.fr\/sante\/12917-2\/","title":{"rendered":"Une avanc\u00e9e majeure pour les patientes et patients atteints de cancer et d\u2019un trouble thromboembolique"},"content":{"rendered":"

[et_pb_section bb_built=\u00a0\u00bb1″ next_background_color=\u00a0\u00bb#000000″ inner_width=\u00a0\u00bbauto\u00a0\u00bb inner_max_width=\u00a0\u00bbnone\u00a0\u00bb][et_pb_row][et_pb_column type=\u00a0\u00bb3_4″][et_pb_text admin_label=\u00a0\u00bbIntro\u00a0\u00bb _builder_version=\u00a0\u00bb3.22.1″ module_id=\u00a0\u00bbintro\u00a0\u00bb text_text_shadow_horizontal_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ text_text_shadow_vertical_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ text_text_shadow_blur_strength=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ link_text_shadow_horizontal_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ link_text_shadow_vertical_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ link_text_shadow_blur_strength=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ ul_text_shadow_horizontal_length=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ul_text_shadow_vertical_length=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ul_text_shadow_blur_strength=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ol_text_shadow_horizontal_length=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ ol_text_shadow_vertical_length=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ ol_text_shadow_blur_strength=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ quote_text_shadow_horizontal_length=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ quote_text_shadow_vertical_length=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ quote_text_shadow_blur_strength=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ header_text_shadow_horizontal_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_text_shadow_vertical_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_text_shadow_blur_strength=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_2_text_shadow_horizontal_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_vertical_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_blur_strength=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_3_text_shadow_horizontal_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_vertical_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_blur_strength=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_4_text_shadow_horizontal_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_vertical_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_blur_strength=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_5_text_shadow_horizontal_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_vertical_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_blur_strength=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_6_text_shadow_horizontal_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_vertical_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_blur_strength=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ z_index_tablet=\u00a0\u00bb500″]<\/p>\n

Une \u00e9tude internationale, men\u00e9e sous la direction de la Pr Isabelle Mah\u00e9 (Universit\u00e9 Paris Cit\u00e9, AP-HP), r\u00e9v\u00e8le qu\u2019un traitement prolong\u00e9 \u00e0 dose r\u00e9duite d\u2019apixaban est aussi efficace et mieux tol\u00e9r\u00e9 qu\u2019une dose pleine chez les patientes et les patients atteints de cancer trait\u00e9s pour un \u00e9v\u00e9nement thromboembolique veineux (TEV). Publi\u00e9s dans le New England Journal of Medicine<\/em> et pr\u00e9sent\u00e9s au congr\u00e8s de l\u2019American College of Cardiology<\/em>, ces r\u00e9sultats pourraient faire \u00e9voluer les recommandations m\u00e9dicales internationales.<\/p>\n

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Une \u00e9tude d\u2019envergure internationale<\/h2>\n

Cet essai clinique acad\u00e9mique, le premier du genre, a \u00e9t\u00e9 men\u00e9 entre 2018 et 2024 dans 136 centres en Europe et au Canada. Il a inclus 1 766 patientes et patients atteints d\u2019un cancer actif, dont 65,8 % pr\u00e9sentaient des m\u00e9tastases et 81,2 % suivaient un traitement anticanc\u00e9reux. L\u2019objectif \u00e9tait d\u2019\u00e9valuer l\u2019efficacit\u00e9 et la tol\u00e9rance d\u2019une dose r\u00e9duite d\u2019apixaban au-del\u00e0 des six premiers mois de traitement anticoagulant.<\/p>\n

Des r\u00e9sultats prometteurs pour la prise en charge des patients<\/h2>\n

Les conclusions de l\u2019\u00e9tude montrent que la dose r\u00e9duite d\u2019apixaban r\u00e9duit de 25 % le risque de saignements cliniquement significatifs sans augmenter le risque de r\u00e9cidive de maladie thromboembolique veineuse. Cette avanc\u00e9e pourrait modifier les pratiques m\u00e9dicales en encourageant l\u2019adoption d\u2019un traitement prolong\u00e9 \u00e0 dose r\u00e9duite chez les patientes et patients atteints de cancer ayant d\u00e9j\u00e0 re\u00e7u six mois d\u2019anticoagulation. Une mise \u00e0 jour des recommandations internationales est attendue afin d\u2019am\u00e9liorer la prise en charge de ces patientes et patients vuln\u00e9rables.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_4″][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=\u00a0\u00bb1″ specialty=\u00a0\u00bboff\u00a0\u00bb _builder_version=\u00a0\u00bb3.21″ custom_padding=\u00a0\u00bb0px||0px|\u00a0\u00bb prev_background_color=\u00a0\u00bb#000000″ inner_width=\u00a0\u00bbauto\u00a0\u00bb inner_max_width=\u00a0\u00bbnone\u00a0\u00bb][et_pb_row _builder_version=\u00a0\u00bb3.19.11″ width=\u00a0\u00bb80%\u00a0\u00bb max_width=\u00a0\u00bb1080px\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″][et_pb_text admin_label=\u00a0\u00bb\u00c0 lire aussi\u00a0\u00bb _builder_version=\u00a0\u00bb3.21″]<\/p>\n

\u00c0<\/span> lire aussi<\/h2>\n

[\/et_pb_text][et_pb_blog _builder_version=\u00a0\u00bb3.21″ posts_number=\u00a0\u00bb4″ include_categories=\u00a0\u00bb13″ show_author=\u00a0\u00bboff\u00a0\u00bb show_date=\u00a0\u00bboff\u00a0\u00bb show_pagination=\u00a0\u00bboff\u00a0\u00bb border_width_bottom_fullwidth=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom_fullwidth=\u00a0\u00bbrgba(51,51,51,0.18)\u00a0\u00bb custom_padding=\u00a0\u00bb||50px|\u00a0\u00bb module_id=\u00a0\u00bbpage_type_blog\u00a0\u00bb header_level=\u00a0\u00bbh4″ \/][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div> Une \u00e9tude internationale, men\u00e9e sous la direction de la Pr Isabelle Mah\u00e9 (Universit\u00e9 Paris Cit\u00e9, AP-HP), r\u00e9v\u00e8le qu\u2019un traitement prolong\u00e9 \u00e0 dose r\u00e9duite d\u2019apixaban est aussi efficace et mieux tol\u00e9r\u00e9 qu\u2019une dose pleine chez les patientes et les patients atteints de cancer trait\u00e9s pour un \u00e9v\u00e9nement thromboembolique veineux (TEV). Publi\u00e9s dans le New England… Lire la suite Une avanc\u00e9e majeure pour les patientes et patients atteints de cancer et d\u2019un trouble thromboembolique<\/span><\/a><\/p>\n","protected":false},"author":185,"featured_media":12926,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[1,17],"tags":[],"coauthors":[52],"class_list":["post-12917","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculte-de-sante","category-recherche"],"_links":{"self":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/12917","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/users\/185"}],"replies":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/comments?post=12917"}],"version-history":[{"count":5,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/12917\/revisions"}],"predecessor-version":[{"id":12936,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/12917\/revisions\/12936"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/media\/12926"}],"wp:attachment":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/media?parent=12917"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/categories?post=12917"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/tags?post=12917"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/coauthors?post=12917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}