
{"id":13347,"date":"2025-04-09T15:24:12","date_gmt":"2025-04-09T13:24:12","guid":{"rendered":"https:\/\/u-paris.fr\/sante\/?p=13347"},"modified":"2025-08-27T15:29:34","modified_gmt":"2025-08-27T13:29:34","slug":"keynote-recherche-aurelien-de-reynies-exploration-de-lheterogeneite-intra-tumorale-a-partir-du-transcriptome","status":"publish","type":"post","link":"https:\/\/u-paris.fr\/sante\/keynote-recherche-aurelien-de-reynies-exploration-de-lheterogeneite-intra-tumorale-a-partir-du-transcriptome\/","title":{"rendered":"[Keynote recherche] Aur\u00e9lien de Reyni\u00e8s, Exploration de l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 intra-tumorale \u00e0 partir du transcriptome"},"content":{"rendered":"<p>[et_pb_section bb_built=\u00a0\u00bb1&Prime; next_background_color=\u00a0\u00bb#000000&Prime; inner_width=\u00a0\u00bbauto\u00a0\u00bb inner_max_width=\u00a0\u00bbnone\u00a0\u00bb][et_pb_row][et_pb_column type=\u00a0\u00bb3_4&Prime;][et_pb_text admin_label=\u00a0\u00bbIntro\u00a0\u00bb _builder_version=\u00a0\u00bb3.22.1&Prime; module_id=\u00a0\u00bbintro\u00a0\u00bb text_text_shadow_horizontal_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93&Prime; text_text_shadow_vertical_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93&Prime; text_text_shadow_blur_strength=\u00a0\u00bbtext_text_shadow_style,%91object Object%93&Prime; link_text_shadow_horizontal_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93&Prime; link_text_shadow_vertical_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93&Prime; link_text_shadow_blur_strength=\u00a0\u00bblink_text_shadow_style,%91object Object%93&Prime; ul_text_shadow_horizontal_length=\u00a0\u00bbul_text_shadow_style,%91object Object%93&Prime; ul_text_shadow_vertical_length=\u00a0\u00bbul_text_shadow_style,%91object Object%93&Prime; ul_text_shadow_blur_strength=\u00a0\u00bbul_text_shadow_style,%91object Object%93&Prime; ol_text_shadow_horizontal_length=\u00a0\u00bbol_text_shadow_style,%91object Object%93&Prime; ol_text_shadow_vertical_length=\u00a0\u00bbol_text_shadow_style,%91object Object%93&Prime; ol_text_shadow_blur_strength=\u00a0\u00bbol_text_shadow_style,%91object Object%93&Prime; quote_text_shadow_horizontal_length=\u00a0\u00bbquote_text_shadow_style,%91object Object%93&Prime; quote_text_shadow_vertical_length=\u00a0\u00bbquote_text_shadow_style,%91object Object%93&Prime; quote_text_shadow_blur_strength=\u00a0\u00bbquote_text_shadow_style,%91object Object%93&Prime; header_text_shadow_horizontal_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93&Prime; header_text_shadow_vertical_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93&Prime; header_text_shadow_blur_strength=\u00a0\u00bbheader_text_shadow_style,%91object Object%93&Prime; header_2_text_shadow_horizontal_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93&Prime; header_2_text_shadow_vertical_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93&Prime; header_2_text_shadow_blur_strength=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93&Prime; header_3_text_shadow_horizontal_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93&Prime; header_3_text_shadow_vertical_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93&Prime; header_3_text_shadow_blur_strength=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93&Prime; header_4_text_shadow_horizontal_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93&Prime; header_4_text_shadow_vertical_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93&Prime; header_4_text_shadow_blur_strength=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93&Prime; header_5_text_shadow_horizontal_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93&Prime; header_5_text_shadow_vertical_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93&Prime; header_5_text_shadow_blur_strength=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93&Prime; header_6_text_shadow_horizontal_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93&Prime; header_6_text_shadow_vertical_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93&Prime; header_6_text_shadow_blur_strength=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93&Prime; z_index_tablet=\u00a0\u00bb500&Prime;]<\/p>\n<p><em><strong>Aur\u00e9lien de Reyni\u00e8s<\/strong> est bio-informaticien, PUPH en canc\u00e9rologie \u00e0 l\u2019Universit\u00e9 Paris Cit\u00e9 et membre du Centre de Recherche des Cordeliers o\u00f9 il dirige l\u2019\u00e9quipe MUST (Mod\u00e9lisation multi-\u00e9chelles et spatio-temporelle en canc\u00e9rologie). Il est aussi responsable du DIU Mod\u00e9lisation multi-\u00e9chelles de la complexit\u00e9 tumorale.<\/em><\/p>\n<p>Dans cette conf\u00e9rence, il pr\u00e9sente ses travaux sur l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 intra-tumorale. En effet, dans une m\u00eame tumeur d\u2019un patient, on peut retrouver plusieurs types de cellules diff\u00e9rents, que ces derni\u00e8res soient tumorales ou non. Or, cette h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 est une cause majeure de r\u00e9sistance aux traitements.\u00a0 Des m\u00e9thodes bio-informatiques bas\u00e9es sur le transcriptome (ensemble des ARN issus de la transcription du g\u00e9nome) permettent d\u2019\u00e9tudier cette h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 pour mieux pr\u00e9dire le comportement des tumeurs.<\/p>\n<p>Cette conf\u00e9rence a eu lieu le 8 avril 2025.\u00a0<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_4&Prime;][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=\u00a0\u00bb3_4&Prime;][et_pb_text _builder_version=\u00a0\u00bb3.22.1&Prime; module_id=\u00a0\u00bbcontenu\u00a0\u00bb text_text_shadow_horizontal_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93&Prime; text_text_shadow_vertical_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93&Prime; text_text_shadow_blur_strength=\u00a0\u00bbtext_text_shadow_style,%91object Object%93&Prime; link_text_shadow_horizontal_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93&Prime; 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header_text_shadow_horizontal_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93&Prime; header_text_shadow_vertical_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93&Prime; header_text_shadow_blur_strength=\u00a0\u00bbheader_text_shadow_style,%91object Object%93&Prime; header_2_text_shadow_horizontal_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93&Prime; header_2_text_shadow_vertical_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93&Prime; header_2_text_shadow_blur_strength=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93&Prime; header_3_text_shadow_horizontal_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93&Prime; header_3_text_shadow_vertical_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93&Prime; header_3_text_shadow_blur_strength=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93&Prime; header_4_text_shadow_horizontal_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93&Prime; header_4_text_shadow_vertical_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93&Prime; header_4_text_shadow_blur_strength=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93&Prime; header_5_text_shadow_horizontal_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93&Prime; header_5_text_shadow_vertical_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93&Prime; header_5_text_shadow_blur_strength=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93&Prime; header_6_text_shadow_horizontal_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93&Prime; header_6_text_shadow_vertical_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93&Prime; header_6_text_shadow_blur_strength=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93&Prime; z_index_tablet=\u00a0\u00bb500&Prime;]<\/p>\n<p><iframe loading=\"lazy\" title=\"Aur\u00e9lien de Reyni\u00e8s Exploration de l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 intra-tumorale \u00e0 partir du transcriptome 08\/04\/25\" width=\"1080\" height=\"608\" src=\"https:\/\/www.youtube.com\/embed\/fdsskojBHd8?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_4&Prime;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=\u00a0\u00bb1&Prime; specialty=\u00a0\u00bboff\u00a0\u00bb _builder_version=\u00a0\u00bb3.21&Prime; custom_padding=\u00a0\u00bb0px||0px|\u00a0\u00bb prev_background_color=\u00a0\u00bb#000000&Prime; inner_width=\u00a0\u00bbauto\u00a0\u00bb inner_max_width=\u00a0\u00bbnone\u00a0\u00bb][et_pb_row _builder_version=\u00a0\u00bb3.19.11&Prime; width=\u00a0\u00bb80%\u00a0\u00bb max_width=\u00a0\u00bb1080px\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime;][et_pb_text admin_label=\u00a0\u00bb\u00c0 lire aussi\u00a0\u00bb _builder_version=\u00a0\u00bb3.21&Prime;]<\/p>\n<h2><span class=\"st\">\u00c0<\/span> lire aussi<\/h2>\n<p>[\/et_pb_text][et_pb_blog _builder_version=\u00a0\u00bb3.21&Prime; posts_number=\u00a0\u00bb4&Prime; include_categories=\u00a0\u00bb13&Prime; show_author=\u00a0\u00bboff\u00a0\u00bb show_date=\u00a0\u00bboff\u00a0\u00bb show_pagination=\u00a0\u00bboff\u00a0\u00bb border_width_bottom_fullwidth=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom_fullwidth=\u00a0\u00bbrgba(51,51,51,0.18)\u00a0\u00bb custom_padding=\u00a0\u00bb||50px|\u00a0\u00bb module_id=\u00a0\u00bbpage_type_blog\u00a0\u00bb header_level=\u00a0\u00bbh4&Prime; \/][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_row et_pb_row_0 et_pb_row_empty\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div> Aur\u00e9lien de Reyni\u00e8s est bio-informaticien, PUPH en canc\u00e9rologie \u00e0 l\u2019Universit\u00e9 Paris Cit\u00e9 et membre du Centre de Recherche des Cordeliers o\u00f9 il dirige l\u2019\u00e9quipe MUST (Mod\u00e9lisation multi-\u00e9chelles et spatio-temporelle en canc\u00e9rologie). Il est aussi responsable du DIU Mod\u00e9lisation multi-\u00e9chelles de la complexit\u00e9 tumorale.Dans cette conf\u00e9rence, il pr\u00e9sente ses travaux sur l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 intra-tumorale. En effet,&hellip; <a class=\"continue\" href=\"https:\/\/u-paris.fr\/sante\/keynote-recherche-aurelien-de-reynies-exploration-de-lheterogeneite-intra-tumorale-a-partir-du-transcriptome\/\">Lire la suite<span> [Keynote recherche] Aur\u00e9lien de Reyni\u00e8s, Exploration de l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 intra-tumorale \u00e0 partir du transcriptome<\/span><\/a><\/p>\n","protected":false},"author":185,"featured_media":13348,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[1,61],"tags":[],"coauthors":[52],"class_list":["post-13347","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculte-de-sante","category-keynotes-fr"],"_links":{"self":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/13347","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/users\/185"}],"replies":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/comments?post=13347"}],"version-history":[{"count":1,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/13347\/revisions"}],"predecessor-version":[{"id":13349,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/13347\/revisions\/13349"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/media\/13348"}],"wp:attachment":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/media?parent=13347"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/categories?post=13347"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/tags?post=13347"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/coauthors?post=13347"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}