{"id":14509,"date":"2026-01-07T12:04:27","date_gmt":"2026-01-07T11:04:27","guid":{"rendered":"https:\/\/u-paris.fr\/sante\/?p=14509"},"modified":"2026-01-07T12:04:54","modified_gmt":"2026-01-07T11:04:54","slug":"une-nouvelle-application-web-pour-decrypter-la-regulation-post-transcriptionnelle","status":"publish","type":"post","link":"https:\/\/u-paris.fr\/sante\/une-nouvelle-application-web-pour-decrypter-la-regulation-post-transcriptionnelle\/","title":{"rendered":"Une nouvelle application web pour d\u00e9crypter la r\u00e9gulation post-transcriptionnelle"},"content":{"rendered":"

[et_pb_section fb_built=\u00a0\u00bb1″ _builder_version=\u00a0\u00bb3.22″][et_pb_row _builder_version=\u00a0\u00bb3.22″ background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb3_4″ _builder_version=\u00a0\u00bb3.0.47″][et_pb_text admin_label=\u00a0\u00bbIntro\u00a0\u00bb module_id=\u00a0\u00bbintro\u00a0\u00bb _builder_version=\u00a0\u00bb3.22.1″]<\/p>\n

Une \u00e9tude de l’Institut Cochin publi\u00e9e dans Communications Biology<\/em> (Nature Portfolio) apporte un nouvel \u00e9clairage sur la r\u00e9gulation post\u2011transcriptionnelle de l\u2019expression des g\u00e8nes dans la leuc\u00e9mie aigu\u00eb my\u00e9lo\u00efde (LAM). En combinant des donn\u00e9es transcriptomiques et prot\u00e9omiques issues de patients atteints de LAM, les auteurs montrent que le ratio prot\u00e9ine\/ARNm (PTR) constitue un indicateur robuste et conserv\u00e9 des r\u00e9gulations post-transcriptionnelles chez ces patients. L\u2019\u00e9tude identifie les d\u00e9terminants mol\u00e9culaires majeurs contr\u00f4lant la traduction, la stabilit\u00e9 et la localisation des ARNm, et introduit un nouvel outil, POSTCODE, pour analyser ces m\u00e9canismes dans tout type de mod\u00e8le et \u00e0 grande \u00e9chelle.<\/p>\n

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Sch\u00e9ma de l’outil POSTCODE, d\u00e9velopp\u00e9 par l’Institut Cochin<\/div>\n<\/div>\n<\/div>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb3.22″ background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb3.0.47″][et_pb_text admin_label=\u00a0\u00bbl\u00e9gende\u00a0\u00bb module_id=\u00a0\u00bblegende\u00a0\u00bb _builder_version=\u00a0\u00bb3.22.1″]<\/p>\n

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\u00a9 Institut Cochin<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Mise en \u00e9vidence d\u2019une r\u00e9gulation post-transcriptionnelle conserv\u00e9e dans la LAM<\/h2>\n

L\u2019expression des g\u00e8nes ne se limite pas \u00e0 la transcription : de nombreux m\u00e9canismes post\u2011transcriptionnels contr\u00f4lent la traduction des ARNm en prot\u00e9ines, leur stabilit\u00e9 ou leur s\u00e9questration cellulaire. Dans la leuc\u00e9mie aigu\u00eb my\u00e9lo\u00efde (LAM), ces processus restent encore mal caract\u00e9ris\u00e9s \u00e0 l\u2019\u00e9chelle globale.<\/p>\n

Dans cette \u00e9tude, les chercheurs de l\u2019Institut Cochin, en collaboration avec plusieurs partenaires nationaux et internationaux ont int\u00e9gr\u00e9 des donn\u00e9es transcriptomiques et prot\u00e9omiques provenant de 44 patients atteints de LAM afin de calculer les ratios prot\u00e9ine\/ARNm (PTR), un param\u00e8tre synth\u00e9tique refl\u00e9tant l\u2019ensemble des r\u00e9gulations post\u2011transcriptionnelles. Ils montrent que ces PTR sont remarquablement conserv\u00e9s entre patients, sous\u2011types de LAM et m\u00eame entre diff\u00e9rents tissus humains, sugg\u00e9rant l\u2019existence de m\u00e9canismes fondamentaux et universels.<\/p>\n

D\u00e9terminants mol\u00e9culaires des PTR et d\u00e9veloppement de l\u2019outil POSTCODE<\/h2>\n

L\u2019analyse d\u00e9taill\u00e9e de plus d\u2019un millier de \u00ab proxys \u00bb (caract\u00e9ristiques) mol\u00e9culaires \u2014 li\u00e9s aux r\u00e9gions 5\u2019UTR, CDS et 3\u2019UTR des ARNm, ainsi qu\u2019aux propri\u00e9t\u00e9s des prot\u00e9ines \u2014 permet d\u2019identifier les d\u00e9terminants cl\u00e9s de ces PTR. Ces d\u00e9terminants incluent notamment l\u2019efficacit\u00e9 de l\u2019initiation et de l\u2019\u00e9longation de la traduction, la composition en codons, la stabilit\u00e9 des ARNm et leur localisation subcellulaire.<\/p>\n

Enfin, les auteurs d\u00e9veloppent POSTCODE, un outil bioinformatique destin\u00e9 \u00e0 annoter des jeux de donn\u00e9es \u00ab\u00a0omiques\u00a0\u00bb (transcriptomique, prot\u00e9omique, ribosome profiling) \u00e0 partir de ces proxys. POSTCODE permet ainsi de r\u00e9v\u00e9ler des r\u00e9gulations post-transcriptionnelles jusque-l\u00e0 invisibles dans les analyses classiques, ouvrant de nouvelles perspectives pour la compr\u00e9hension de la LAM et l\u2019identification de strat\u00e9gies de m\u00e9decine de pr\u00e9cision.<\/p>\n

POSTCODE est propos\u00e9 sous la forme d\u2019une application web user\u2011friendly, utilisable sans aucune comp\u00e9tence en programmation, et applicable \u00e0 tout type de probl\u00e9matique biologique humaine, au-del\u00e0 du seul cadre de la LAM. L\u2019outil est librement accessible \u00e0 l\u2019adresse suivante : https:\/\/postcode-lab.shinyapps.io\/POSTCODE\/<\/a>.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_4″ _builder_version=\u00a0\u00bb3.0.47″][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1″ _builder_version=\u00a0\u00bb3.22″ custom_padding=\u00a0\u00bb0px||0px|\u00a0\u00bb][et_pb_row _builder_version=\u00a0\u00bb3.22″][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb3.0.47″][et_pb_text admin_label=\u00a0\u00bb\u00c0 lire aussi\u00a0\u00bb _builder_version=\u00a0\u00bb3.21″]<\/p>\n

\u00c0<\/span> lire aussi<\/h2>\n

[\/et_pb_text][et_pb_blog posts_number=\u00a0\u00bb4″ include_categories=\u00a0\u00bb13″ show_author=\u00a0\u00bboff\u00a0\u00bb show_date=\u00a0\u00bboff\u00a0\u00bb show_pagination=\u00a0\u00bboff\u00a0\u00bb module_id=\u00a0\u00bbpage_type_blog\u00a0\u00bb _builder_version=\u00a0\u00bb3.21″ header_level=\u00a0\u00bbh4″ border_width_bottom_fullwidth=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom_fullwidth=\u00a0\u00bbrgba(51,51,51,0.18)\u00a0\u00bb custom_padding=\u00a0\u00bb||50px|\u00a0\u00bb][\/et_pb_blog][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Une \u00e9tude de l’Institut Cochin publi\u00e9e dans Communications Biology (Nature Portfolio) apporte un nouvel \u00e9clairage sur la r\u00e9gulation post\u2011transcriptionnelle de l\u2019expression des g\u00e8nes dans la leuc\u00e9mie aigu\u00eb my\u00e9lo\u00efde (LAM). En combinant des donn\u00e9es transcriptomiques et prot\u00e9omiques issues de patients atteints de LAM, les auteurs montrent que le ratio prot\u00e9ine\/ARNm (PTR) constitue un indicateur robuste et… Lire la suite Une nouvelle application web pour d\u00e9crypter la r\u00e9gulation post-transcriptionnelle<\/span><\/a><\/p>\n","protected":false},"author":185,"featured_media":14516,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[1,17],"tags":[],"coauthors":[52],"class_list":["post-14509","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculte-de-sante","category-recherche"],"_links":{"self":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/14509","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/users\/185"}],"replies":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/comments?post=14509"}],"version-history":[{"count":4,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/14509\/revisions"}],"predecessor-version":[{"id":14517,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/posts\/14509\/revisions\/14517"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/media\/14516"}],"wp:attachment":[{"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/media?parent=14509"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/categories?post=14509"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/tags?post=14509"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/u-paris.fr\/sante\/wp-json\/wp\/v2\/coauthors?post=14509"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}